China Food

Harvard University research confirmed the gastrointestinal health effect of hyaluronic acid, and hyaluronic acid food is expected to explore new application scenarios?

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moves forward in numerous disputes. Will hyaluronic acid food track be the next new blue ocean?
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The trend is changing, but consumers’ desire for beauty has never stopped.
 
From the popular oral beauty product “collagen”, to the bird’s nest, which focuses on beauty conditioning, to the emerging “net red” soap horn rice and peach gum, as well as the popularity of paragraphs such as “soaking medlar in a thermos cup” and “punk health preservation”, more and more young people join the attempt of oral beauty products.
 
Oral beauty products have become a new growth point of “beauty economy”, and have also spawned one hot category after another in the food industry. In 2021, hyaluronic acid food was “born in the sky” and joined the “war situation”, which has won the pursuit of consumers and the frequent attention of the industry with its unique functional attributes.
 
Will hyaluronic acid food be the next blue ocean?
 
 
Attacking hyaluronic acid:
The next functional food new blue ocean?
 
As the intersection of health care and skin care consumption, functional foods have formed a wide market in the world from the needs of beauty, body, body, and defecation, such as whitening, anti aging, water supplement, anti stripping, thin body and breast enhancement.
 
As an important additive in functional foods, hyaluronic acid food has a long history of approval abroad. In 1996, hyaluronic acid was officially listed as an additive in health products in Japan, and pola, FANCL, DHC, Shiseido and other companies launched a number of best-selling hyaluronic acid products. After 2000, hyaluronic acid began to be used on a large scale in the field of nutritional food, with more than 2000 types of hyaluronic acid in the world There are more than 160 kinds of sour foods listed in Japan alone, and a variety of foods containing hyaluronic acid are also sold in the United States, Britain, Canada, the Czech Republic, Brazil and other countries.
 
American Joint nutrition and health care brand move free Yijie weiguli is mainly composed of hyaluronic acid
 
Most of the raw materials of hyaluronic acid food popular all over the world come from China. For a long time, Chinese enterprises have been the world leader in the sales of hyaluronic acid raw materials. According to the latest report in 2020, the total sales of hyaluronic acid raw materials in China account for 81.6% of the global sales, and Chinese enterprises rank first in the global sales. Among them, Huaxi Biology (688363. SH) It is the world’s largest hyaluronic acid production and sales enterprise, accounting for 43% of global sales in 2020, and the global sales of hyaluronic acid of focus biology, Fufeng biology and Anhua biology accounted for 15%, 8% and 7% respectively, ranking second to fourth.
Before the approval of hyaluronic acid into food by the National Health Commission, these hyaluronic acid raw materials exported from China were produced abroad as terminal hyaluronic acid food, and were returned to China by consumers at dozens of times the price, which were used by Chinese consumers in bone and joint treatment, beauty and other directions.
 
On January 7, 2021, the National Health Commission officially approved the sodium hyaluronate (hyaluronic acid, commonly known as “hyaluronic acid”) declared by Huaxi biology For the request of new food raw materials, it is allowed to add and use in ordinary food, including milk and dairy products, beverages, wines, cocoa products, chocolate and chocolate products, candy, frozen drinks, etc. since then, a new era of hyaluronic acid food localization has been ushered in.
 
The food policy of hyaluronic acid undoubtedly has cross era significance in the field of hyaluronic acid industry, which not only means that the state recognizes the safety of hyaluronic acid as food, but also deeply empowers the food industry of hyaluronic acid. This policy has solved the “bayonet” of terminal food production and processing, and domestic hyaluronic acid manufacturers have been able to return all terminal processing and sales links to China, opened up the whole hyaluronic acid industry chain of Chinese enterprises, and opened a new competition of functional food for Chinese hyaluronic acid enterprises.
 
Following the policy, a large number of hyaluronic acid foods emerged in less than a year, and hyaluronic acid foods ushered in a new form of letting a hundred flowers bloom. In the social tiktok, Xiaohong book and other social platforms, hyaluronic acid foods are also receiving the attention of consumers, and gradually recognized by the market.
 
But can domestic hyaluronic acid food “rise up in the wind” and develop a vast new blue sea? This may need to experience the double test of product efficacy and industrialization.
A variety of hyaluronic acid application categories on the market
After Tokyo University of agriculture and technology in Japan,
Harvard University study confirms the gastrointestinal health efficacy of oral hyaluronic acid
 
The intake of hyaluronic acid opens a new food track, followed by doubts about its efficacy by consumers and academia. “Can hyaluronic acid really be eaten? Is it safe?” “does oral products really work?” “what benefits can hyaluronic acid bring to the human body?” and other issues have also become the focus of most consumers. Most of these questions are because people have formed a fixed thinking mode about the application of hyaluronic acid in beauty, medical and other scenes.
 
Is oral hyaluronic acid safe?
 
Whether we know hyaluronic acid or not, the first reaction to this substance may be added to medical and beauty drugs and cosmetics. In fact, hyaluronic acid, known as “hyaluronic acid”, is an acidic mucopolysaccharide and a natural substance from the human body. Its total content in human body is about 15g, which widely exists in eyeball, knee synovial fluid and skin. It was first extracted from bovine eyes in 1934. Hyaluronic acid was also found in chicken crowns and fish oil. Therefore, as a natural food, the edible safety of hyaluronic acid has its foundation.
 
In China, the application for adding new substances in the food field is extremely strict. Behind the national approval of hyaluronic acid as an additive to ordinary food, it has experienced many years of rigorous experiments. As early as 2004, Huaxi biological started the application of hyaluronic acid as a food additive for the first time in China, and conducted a long-term experiment on the safety of hyaluronic acid based on basic research and applied basic research. Liu Ming, assistant director of national food fermentation standardization center and professor level senior engineer of China Food Fermentation Industry Research Institute, said: “Hyaluronic acid is a new raw material for biological fermentation. According to the management regulations and very detailed review rules, we have conducted detailed research on the production strains and production process, various toxicologies of the raw materials, as well as dietary exposure and risk assessment.” it can be said that “hyaluronic acid ingestion” has confirmed the safety of oral hyaluronic acid.
 
Can oral hyaluronic acid be absorbed and utilized by the human body?
 
Relevant investigations and studies show that hyaluronic acid is absorbed in the intestine in the form of monosaccharide or non monosaccharide with small molecular weight, and then re synthesized into macromolecular hyaluronic acid under the action of synthase in the body. In the summer of 2021, the nature portfolio of nature, an international authoritative journal, also published the title “from mechanism research to experimental analysis: oral hyaluronic acid improves skin moisture?” In the experiment, 90% of oral hyaluronic acid can be absorbed and utilized by the body, and some can remain in the skin tissue, which confirms the absorption mechanism and safety of oral hyaluronic acid. This means that oral hyaluronic acid actually acts on the health behavior of all human beings. If our other parts need hyaluronic acid more than the skin, the body will use these Raw materials give priority to the synthesis of hyaluronic acid in other parts, but the skin will also benefit.
 
What benefits can eating hyaluronic acid bring to the human body?
in view of this problem, the research and exploration in the scientific community are deepening.
 
In the direction of beauty, explore the change of hyaluronic acid to human skin state. At present, the academic community has issued a number of research reports, which have proved the product efficacy of hyaluronic acid to a certain extent through a series of scientific research methods such as double-blind experiments.
 
  • The research on ingested hyaluronans cosmetics dry skin published in the Nutrition Journal in 2014 confirmed that eating hyaluronic acid can improve dry skin and reduce wrinkles;
  • A randomized controlled clinical study published in the Journal of clinical and cosmetic dermatology by Italian scholar guaitolini et al. In 2019 showed that after continuous administration of hyaluronic acid for 60 days, the skin water content, skin elasticity and wrinkles of the experimental group were significantly improved;
  • Hunan Center for Disease Control and Prevention conducted a test on haplexplus, a food grade hyaluronic acid raw material produced by Huaxi biological (688363. SH), the boss of hyaluronic acid. It showed that hyaluronic acid could increase skin moisture and had antioxidant effect. After oral administration of hyaluronic acid, the skin moisture content increased by 9%, which was significantly higher than that of those who did not take hyaluronic acid.
 
In terms of promoting human health, the study found that hyaluronic acid can promote gastrointestinal health, the treatment of dry eye and bone and joint inflammation. Hyaluronic acid can also play a key role in joint lubrication, vascular wall permeability regulation and wound healing.
 
  • Tokyo a & M University and the R & D Department of kewpie company published in the Journal of medical food in 2017 to discuss the research results on the degradation and absorption of oral hyaluronic acid in the gastrointestinal tract;
  • In 2020, Hokkaido University of Japan published in the European Journal of pharmaceuticals and biopharmaceutics. The research on the transfer of oral hyaluronic acid to the lymphatic system and blood showed that hyaluronic acid with large molecular weight can be degraded into oligohyaluronic acid with smaller molecular weight through microorganisms in the intestine, and the molecular weight is less than 10000. In this way, the molecular weight of hyaluronic acid can be further transferred to the blood and lymph, which is beneficial to the organs that need hyaluronic acid.
  • In 2019, the clinical study of oral hyaluronic acid to alleviate dry eye disease conducted by Korean scientists showed that the symptoms were significantly improved when oral hyaluronic acid was used together with eye drops hyaluronic acid.
  • In the treatment of osteoarthritis, oral intake of hyaluronic acid has also been found in relevant studies that it can bind to toll like receptor-4 and promote the expression of interleukin-10 and cytokine signal transduction. These two signals are of great value in alleviating and treating osteoarthritis.
 
At the same time, recently, a joint scientific research conducted by scientific research institutions such as the mucosal immunity and biology research center of Massachusetts General Hospital of Harvard University Medical Department and Beijing University of traditional Chinese medicine in China released a major research achievement on hyaluronic acid The change of intestinal microbiota induced by hyaluronic acid is helpful for mice to resist rodent Citrobacter infection and improve intestinal inflammation, which provides theoretical support for the application of hyaluronic acid in food. This achievement is published in the medical journal gut microbes (edited by Beth McCormick, influencing factor (2020): 10.245) Research shows that oral hyaluronic acid plays an important role in improving intestinal inflammation, promoting the growth of probiotics and regulating intestinal barrier function.
 
The data showed that hyaluronic acid could selectively change the composition of intestinal microbiome and metabolites in mice
 
In this study, scientists found that hyaluronic acid changed the intestinal microbial composition of BALB / c mice, helped mice resist rodent Citrobacter infection, reduced the imbalance of intestinal flora induced by rodent Citrobacter, regulated the immune response and intestinal epithelial barrier function of mice during rodent Citrobacter infection, and alleviated intestinal inflammation. Relevant studies also showed that hyaluronic acid Acid is beneficial to a variety of diseases, including intestinal inflammatory diseases.
 
Through in-depth exploration of this phenomenon, scientists believe that the intake of hyaluronic acid can selectively promote the growth of probiotics in the intestine, especially Ackermann’s bacteria. Ackermann’s bacteria can increase the number of goblet cells and mucin in the intestine of mice infected with rodent Citrobacter, enhance intestinal resistance and reduce intestinal inflammation by regulating the mucosal barrier of the intestine The latest discovery of Harvard University has opened up a new application direction of hyaluronic acid products in addition to skin care and beauty, bone health and eye diseases.
 
The industry can be expected,
Strengthening consumer awareness is the key
 
In addition to the verification of efficacy, the industrial development environment of hyaluronic acid food also determines the continuous development of hyaluronic acid food.
 
In developed countries with relatively mature hyaluronic acid industry, such as the United States and Japan, the exploration of hyaluronic acid food has become increasingly perfect, forming diversified product series such as skin health, intestinal health, fat burning and sports function supplement, as well as beverages, dairy products, convenience foods, biscuits, frozen drinks, potato and puffed food, candy products, tea and related products There are a variety of products, such as, wine, cocoa, roasted coffee products and pastries. Consumers’ product cognition is also becoming more and more mature. Hyaluronic acid yogurt and oolong tea have become popular categories.
In contrast, China only started the exploration of food industrialization in 2021. Huaxi biology launched China’s first hyaluronic acid food brand “black zero”, and developed six hyaluronic acid products such as sodium hyaluronate oral liquid, oral disposable, soft candy, tablet candy and jelly. The new food consumption is “net red” Hankou No.2 factory and wonder lab, a substitute food brand, followed suit and launched products such as hyaluronic acid bubble water and hyaluronic acid soft candy. However, compared with the expansion of mature hyaluronic acid food categories in Europe and America, the product types are still in the stage of “curiosity hunting”.
 
Why is hyaluronic acid food not “popular” in China? Maybe we can find out by putting hyaluronic acid food back into the development of the whole functional food track.
 
On the one hand, the per capita consumption expenditure and penetration rate of functional foods in China are far lower than those in developed markets, and consumer awareness is also insufficient. Americans spend an average of $90 a year on oral functional foods and health care products, while Australians spend $222, while Chinese spend only $30. The penetration rate of health care products in the United States is 55%, while that in China is less than 20% As far as hyaluronic acid products are concerned, taking the development of hyaluronic acid food as an example, as early as 2000, the application of hyaluronic acid in the field of nutritional food in the European and American markets has exceeded the field of beauty, and has been deeply cultivated in the direction of health for a long time.
 
Per capita expenditure on health care products in major countries
On the other hand, in the current functional food market, there is still the phenomenon of “worshiping foreign countries and fawning on foreign countries”. Domestic consumers are more convinced of imported brand products and do not have high overall recognition of domestic brands. China’s functional food market has been monopolized by foreign brands such as Swisse, pola, FANCL and aojiabao. It can be seen from the list of top 20 sales of double eleven health care products in 2020 that the domestic functional food market is still the world of overseas brands. Overseas hyaluronic acid functional food is increasingly recognized by consumers, and the product consumption trend continues to show an upward trend. The representative product is Swisse Shuiguang tablet (the main component is hyaluronic acid), which leads the sales of tmall global.
 
The obstacle to the development of hyaluronic acid food and even the whole functional food track is attributed to consumers’ product education and brand trust. Breaking through the bottleneck of consumer education and ushering in the all-round development of functional food track requires the multi-dimensional efforts of the government, scientific research institutions, head brands and other subjects.
 
First, “product power” and “strong efficacy” are the core competitiveness from beginning to end. Functional food racing track and scientific basic support are the core. At present, the research on the improvement of intestinal health of hyaluronic acid with different molecular weight segments released by Harvard Medical School and the action mechanism of oral hyaluronic acid on human bones, joints and eyes jointly studied by Jiangnan University are effectively promoting the efficacy and product capacity of hyaluronic acid food.
 
Second, the industry standard is the cornerstone of the industrial construction of functional food. The government, industry organizations, research institutions and leading enterprises should jointly promote the establishment of standardized, transparent and reliable industry standards to ensure the safe and effective application of bioactives in functional foods. It is reported that at present, the national food fermentation standardization center and Huaxi biology are jointly promoting the revision and updating of relevant standards of hyaluronic acid in food, involving raw material requirements, inspection methods, functional identification and evaluation, so as to avoid the possible shoddy and false identification of large-scale products in the market.
 
Third, in the construction of functional food industry, the head brand is the main body as the producer and seller of products. Enterprises should pay close attention to the pain points of consumers and constantly launch new products in line with consumer expectations with a keen business sense.
 
With the post-90s and post-95s becoming the main consumers, it can be observed that consumers’ cognition of functional food is gradually changing. Tmall data show that in 2020, the sales growth of snacks related to functional foods in the market was as high as 40%, most of the buyers were post-90s, and generation Z was the core user. According to the 2020 functional snack innovation trend, the functional food market is expected to reach 500 billion yuan in the next few years. Eye protection, skin beauty, sleep, boost, immunity and healthy diet are the six main directions in the functional food track.
 
Today, the further discovery of the functions of hyaluronic acid in protecting gastrointestinal tract and eyes will undoubtedly further expand the sales territory of hyaluronic acid in functional food tracks. Through the cognitive education of young people, it will also open a new track of hyaluronic acid products. It is believed that with the further development of the efficacy of hyaluronic acid food in gastrointestinal health and other fields, hyaluronic acid food will further usher in public recognition and new development in the food track.
 

reference:

[1] JinggangLan, Lefei Jiao & Hai Ning Shi (2021) Hyaluronan-induced alterations of thegut microbiome protects mice against Citrobacterrodentium infection andintestinal inflammation, Gut Microbes, 13:1, 1972757

[2] Feng Ning, Shi Yanli, Guo Fengxian, Guo Xueping. Study on the improvement of skin moisture and antioxidant effect of oral hyaluronic acid [J]. Food and drugs, 2016,18 (6): 386-390

[3] Guo Xueping, he Yanli, et al. Application of hyaluronic acid in health products [J]. Chinese Journal of biochemical drugs, 2002,23 (1): 49-51

[4]   Bellamy, N., Campbell, J., Welch, V., Gee, T.L., Bourne, R., & Wells, G. A. (2006). Viscosupplementation for thetreatment of osteoarthritis of the knee. Cochrane database of systematicreviews, (2) :CD005321.

[5] GuaitoliniE , Cavezzi A , Cocchi S , et al. Randomized, Placebo-controlled Study of aNutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethanein Facial Skin Aesthetics and Well-being[J]. The Journal of Clinical andAesthetic Dermatology, 2019, 12(4).Sheldon, R, Pinnell, et al. TopicalL-Ascorbic Acid: Percutaneous Absorption Studies[J]. Dermatologic Surgery,2001.

[6] MacchioneIG, Lopetuso LR, Ianiro G, Napoli M, Gibiino G, Rizzatti G, Petito V,Gasbarrini A, Scaldaferri F. Akkermansia muciniphila: key player in metabolicand gastrointestinal disorders. Eur Rev Med Pharmacol Sci. 2019; 23(18):8075–8083. doi:10.26355/ eurrev_ 201909_ nineteen thousand and twenty-four

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